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Zvigadzirwa zvePO zvine zvakanakisa anti-dandruff uye anti-itching mhedzisiro, yakasarudzika anti-dandruff michina, yakanakisa solubility uye recombination, chengetedzo, isiri-chepfu, isingagumbure, uye inonyanya kushandiswa mu shampoo uye zvigadzirwa zvekuchengetedza bvudzi.PO ine yakanakisa antipruritic mhedzisiro, uye zvakare ine sterilization uye deodorization mabasa, saka yakashandiswa mukugezesa lotions kuwana mhedzisiro yakanaka.PO ine yakakura-spectrum kuuraya mhedzisiro pane fungi uye mold, uye ine yakanaka kurapa mhedzisiro patsoka nerukonye rwemaoko.Inogona kushandiswa sekuchengetedza muzvizoro, sebhaktericide musipo, uye sechinhu chinopisa.Naizvozvo, PO ine multifunctional anti-dandruff uye antipruritic bactericide, iyo inoshandiswa zvakanyanya mu shampoo uye zvigadzirwa zvekuchengetedza bvudzi, lotions yekugezesa, cosmetics, uye detergents.

Piroctone olamine, iyo ethanolamine munyu yehydroxamic acid inotorwa Piroctone, is hydroxypyridone anti-mycotic agent.Piroctone olamine inopinda musero membrane uye inoita macomplexes ane ayoni esimbi, inhibiting simba metabolism mumitochondria[1].Piroctone olamine (PO) is ethanolamine munyu wehydroxamic acid derivative Piroctone.Ese maCandida strains anoratidza kushomeka kushoma inhibitory concentrations (MICs) yePiroctone olamine (0.125-0.5 μg/mL) uye Amphotericin B (AMB) (0.03-1 μg/mL).

Iri basa rine chinangwa chekuongorora antifungal basa rePiroctone olamine mukurapa intra-abdominal candidiasis mumuenzaniso wekuedza uchishandisa Swiss mice.Kurapa nePiroctone olamine (0.5 mg / kg) kunoitwa 72 h mushure mekutapukirwa nekutonga kwe intraperitoneal.Kuenzanisa, boka remhuka (n = 6) rinorapwa neAmphotericin B (0.5 mg / kg).Iyo mycological diagnosis inoitwa nekuunganidza chiropa, spleen uye itsvo.Dhata maererano nekukura kwefungal uye kufa kunoongororwa statistically neMudzidzi bvunzo uye ongororo yekusiyana, ine nhanho yekukosha yakaiswa paP.<0.05.Musiyano mukukura kwefungal scoring pakati peboka rekutonga nemapoka ekurapa (Piroctone olamine neAmphotericin B) yakakosha zvakanyanya (P.<0.05)